Tandem alpha-Arylation/Cyclization of 4-Haloacetoacetates with Arynes: A Metal-Free Approach toward 4-Aryl-3-(2H)-furanones

dc.contributor.author	J, John
dc.contributor.author	V K, Omanakuttan
dc.contributor.author	T, Aneeja
dc.contributor.author	C H, Suresh
dc.contributor.author	P G, Jones
dc.contributor.author	H, Hopf
dc.date.accessioned	2020-02-25T14:44:32Z
dc.date.available	2020-02-25T14:44:32Z
dc.date.issued	2019-04-04
dc.identifier.citation	The Journal of Organic Chemistry; 84(9):5957-5964	en_US
dc.identifier.uri	https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b00488
dc.identifier.uri	http://10.10.100.66:8080/xmlui/handle/123456789/3571
dc.description.abstract	An efficacious, metal-free strategy has been developed for the synthesis of 4-aryl-3-(2H)-furanones. The reaction proceeds via the nucleophilic addition of an active methylene compound to the aryne followed by ring closing of the adduct. The reaction proceeds under mild conditions, is applicable for gram-scale synthesis of 4-aryl-3-(2H)-furanones, and is general for a range of substituted arynes and ring closing	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Furanones	en_US
dc.subject	Ring closing	en_US
dc.title	Tandem alpha-Arylation/Cyclization of 4-Haloacetoacetates with Arynes: A Metal-Free Approach toward 4-Aryl-3-(2H)-furanones	en_US
dc.type	Article	en_US