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Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe

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dc.contributor.author Subramanyan, S
dc.contributor.author Deepika, S
dc.contributor.author Ajith, A
dc.contributor.author Gracy, A J
dc.contributor.author Dan, M
dc.contributor.author Maiti, K K
dc.contributor.author Luxmi Varma, R
dc.contributor.author Radhakrishnan, K V
dc.date.accessioned 2021-11-18T11:07:34Z
dc.date.available 2021-11-18T11:07:34Z
dc.date.issued 2021-10
dc.identifier.citation Chemical Biology & Drug Design; 98(4): 501-506. en_US
dc.identifier.uri https://onlinelibrary.wiley.com/doi/full/10.1111/cbdd.13906
dc.identifier.uri http://hdl.handle.net/123456789/3885
dc.description.abstract Antiproliferative activity was confirmed in the various extracts of rhizomes of Hedychium flavescens (Zingiberaceae). The phytochemical investigation of the rhizomes of Hedychium flavescens led to the isolation of four labdane diterpenes. Their structures were established as coronarin E (1), C-14 epimers of isocoronarin D (2), C-15 epimers of coronarin D methyl ether (3) and isocoronarin D (4). The structure of the compounds was identified based on spectroscopic analysis and on comparison with literature reports. All these compounds were assessed for their in vitro cytotoxicity against human lung adenocarcinoma (A549) cell line and showed significant cytotoxicity as reflected in IC50 value, that is, 0.52, 0.59, 0.68 and 1.22 μM compared with the control doxorubicin (IC50 0.92 μM). Moreover, all the compounds were nontoxic towards the normal lung fibroblast (WI-38) cells. The chemo-profiling and cytotoxicity study of Hedychium flavescens is reported for the first time. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.title Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe en_US
dc.type Article en_US


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    Research articles authored by NIIST researchers published in 2021

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