Abstract:
Nine non-alkaloid constituents viz., sitostenone (1), b-sitosterol (2),
naringenin (3), aromadendrin (4), matairesinol (5), vanillic acid (6),
ferulic acid (7), protocatechuic acid (8) and sitosterol-3-O-b-D-glucopyranoside (9) were isolated from the acetone extract as well
as five alkaloids viz., japindine (10), sarcorucinine D (11), dictyophlebin (12), chonemorphine (13) and N-formylchonemorphine
(14) were isolated from the ethanol extract of Chonemorpha fragrans roots. Except b-sitosterol, all other non-alkaloid compounds
and the alkaloid sarcorucinine D are being reported for the first
time from C. fragrans. From the MIC and MBC values, it has been
found that sarcorucinine D shows most promising antibacterial
activity. Quantification of antibacterial activity as well as killing
curve determinations were performed in order to confirm the efficacy of the compound. The cytotoxic activity studies revealed
that it is nontoxic up to 100 mM concentration.
