Abstract:
A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been
designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have
been confirmed by FTIR, 1H and 13C NMR, and HRMS spectral data. The titled compounds have been evaluated
for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged
quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been
characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has
exhibited excellent anti-inflammatory activity.
