A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

Basavanna, V; Chandramouli, M; Kempaiah, C; Bhadraiah, U K; Lingegowda, N S; Doddamani, S; Ningaiah, S

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dc.contributor.author	Basavanna, V
dc.contributor.author	Chandramouli, M
dc.contributor.author	Kempaiah, C
dc.contributor.author	Bhadraiah, U K
dc.contributor.author	Lingegowda, N S
dc.contributor.author	Doddamani, S
dc.contributor.author	Ningaiah, S
dc.date.accessioned	2022-10-26T09:05:29Z
dc.date.available	2022-10-26T09:05:29Z
dc.date.issued	2021-11
dc.identifier.citation	Russian Journal of General Chemistry;91(11):2257-2266	en_US
dc.identifier.uri	https://doi.org/10.1134/s1070363221110128
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/4117
dc.description.abstract	A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, 1H and 13C NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.	en_US
dc.language.iso	en	en_US
dc.publisher	Springer	en_US
dc.subject	1,3,4-oxadiazole	en_US
dc.subject	pyrazole	en_US
dc.subject	isoxazole	en_US
dc.subject	quinoline	en_US
dc.subject	molecular docking	en_US
dc.subject	antimicrobial	en_US
dc.subject	anti-inflammatory	en_US
dc.title	A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation	en_US
dc.type	Article	en_US