Abstract:
Prevention, accurate diagnosis, and effective treatment of infections are the main challenges in the overall
management of infectious diseases. The best example is the ongoing SARs-COV-2(COVID-19) pandemic;
the entire world is extremely worried about at present. Interestingly, heterocyclic moieties provide an
ideal scaffold on which suitable pharmacophores can be designed to construct novel drugs. Indoles are
amongst the most essential class of heteroaromatics in medicinal chemistry, which are ubiquitous across
natural sources. The aforesaid derivatives have become invaluable scaffolds because of their wide spec-
trum therapeutic applications. Therefore, many researchers are focused on the design and synthesis of
indole and associated hybrids of biological relevance. Hence, in the present review, we concisely discuss
the indole containing natural sources, marketed drugs, clinical candidates, and their biological activities
like antibacterial, antifungal, anti-TB, antiviral, antimalarial, and anti-leishmanial activities. The structure-
activity relationships study of indole derivatives is also presented for a better understanding of the iden-
tified structures. The literature data presented for the anti-infective agents herein covers largely for the
last twelve years.
