Abstract:
Promalabaricone B (PMB), an acylphenol was isolated from
dichloromethane-soluble extract of the seeds of Myrisitica fatua
Houtt. PMB exhibited significant inhibitory activity on a-glucosidase enzyme. The molecular docking and dynamics studies of
PMB with human maltase-glucoamylase were performed. PMB
exhibited an enhanced glucose uptake in L6 myotubes with
46.3% in 2.5 mM. Encouraged with these results; we investigated
the molecular mechanism of PMB through the upregulation of
AMPK. The results revealed that PMB promoted the glucose
uptake in myocytes by stimulating the translocation and expression of GLUT4. From this, it is clear that PMB can acts as a potential therapeutic option for diabetes treatment, and its
hypoglycaemic effect may be mediated by AMPK upregulation
and induction of GLUT4 translocation.
