Abstract:
The critical roles played by advanced glycation endproducts (AGEs) accumulation in
diabetes and diabetic complications have gained intense recognition. AGEs interfere
with the normal functioning of almost every organ with multiple actions like
apoptosis, inflammation, protein dysfunction, mitochondrial dysfunction, and oxidative
stress. However, the development of a potential treatment strategy is yet to
be established. Autophagy is an evolutionarily conserved cellular process that
maintains cellular homeostasis with the degradation and recycling systems. AGEs
can activate autophagy signaling, which could be targeted as a therapeutic strategy
against AGEs induced problems. In this review, we have provided an overview of the
adverse effects of AGEs, and we put forth the notion that autophagy could be a
promising targetable strategy against AGEs.
