Abstract:
The development of environmentally friendly strategies for the synthesis of organic compounds is a fundamental key to
synthetic chemistry. Isoxazole has been constantly evaluated and has been used in many biological applications for a decade. Particularly, isoxazole heterocycle has received countless interest because of various applications in the medicinal,
agrochemical, catalytic and industrial felds. Because of the intensive rate of toxic solvents and additives used within the
synthetic method, greener methods have been adopted using the eco-friendly solvent system, microwave, ultrasonic-induced
and a few nature-friendly techniques for the synthesis of isoxazole analogues. The benefts of the green and efcient synthetic
pathways utilized to create isoxazole analogues are discussed in this literature review. Therefore, the current review thus
presents various greener approaches followed for the synthesis of isoxazole analogues.
