Abstract:
The present review describes the methods reported
for the synthesis of 3(2H)-furanones. This heterocycle forms the
core structure of a number of natural products and biologically
active scaffolds. We have covered all reports available on the
synthesis of 3(2H)-furanone derivatives and have divided the
review into several sections based on the substitution patterns present in the heterocycle. Special emphasis is given to the
generality and the mechanistic rationalizations of each methodology.
In addition, all total syntheses reported for the synthesis
of 3(2H)-furanone containing natural products are reviewed by
highlighting the heterocycle synthesis.
