Inverse Electron Demand Diels Alder Reaction of Aza-o-Quinone Methides and Enaminones: Accessing 3-Aroyl Quinolines and Indeno[1,2-b]quinolinones

dc.contributor.author	Rahul, P
dc.contributor.author	Veena, S
dc.contributor.author	John, Jubi
dc.date.accessioned	2023-03-10T08:11:40Z
dc.date.available	2023-03-10T08:11:40Z
dc.date.issued	2022-09-30
dc.identifier.citation	The Journal of Organic Chemistry; 87(21):13708–13714	en_US
dc.identifier.uri	https://pubs.acs.org/doi/10.1021/acs.joc.2c01361
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/4276
dc.description.abstract	We have developed a Diels Alder cycloaddition route toward 3-aroyl quinolines from enaminones and in situ generated aza-o-quinone methides. The reaction was found to be general with a range of substituted enaminones and aza-o-quinone methides, and we could validate the applicability of the methodology in gram scale. We also demonstrated a one-pot strategy toward 3-acyl quinolines starting from the corresponding aliphatic ketones. Finally, we utilized the 3-aroyl quinolines for synthesizing indeno[1,2-b]quinolinones via a Pd-catalyzed dual C–H activation approach.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.title	Inverse Electron Demand Diels Alder Reaction of Aza-o-Quinone Methides and Enaminones: Accessing 3-Aroyl Quinolines and Indeno[1,2-b]quinolinones	en_US
dc.type	Article	en_US