Abstract:
The development of multifunctional molecular diagnostic platforms for concordant visualization and treatment of
diseases with high sensitivity and resolution has recently become a crucial strategy in cancer management. Thus,
engineering functional metamaterials with high therapeutic and imaging capabilities to elucidate diseases from
morphological behaviors to physiological mechanisms is an unmet need in the current scenario. Here, we report the
design of a unique hybrid plasmonic nanoarchitecture, for targeted multiple photo-therapies of breast cancer by
simultaneous real time monitoring through fluorescence and surface enhanced Raman scattering (SERS) techniques.
The nanoframework consists of plasmonic gold-graphene hybrids tethered with folic acid ligated chitosan modified
photosensitizer (PpIX) to afford target specific localized photothermal and photodynamic therapy. The hybrid vehicle
also served as an excellent nanocarrier for efficient loading and stimuli responsive release of the chemotherapeutic
drug doxorubicin (DOX) to enhance the therapeutic efficacy, thereby forming a trimodal nanomedicine against cancer.
The cytotoxic effects induced by the cumulative action of triplet therapeutic tools were visualized through both
fluorescence and SERS imaging channels. Moreover, it also generated synchronized therapeutic effects resulting in the
effective regression of tumor volume without propagating any toxic effect to other organs of the animals. Taken
together, by virtue of strong light-matter interactions, our nanoprobe showed enhanced photoadsorption which
facilitate the amplified light reactive therapeutic and imaging efficacies along with targeted and enhanced
chemotherapy, both in vitro and in vivo, which may offer a promising outcome in clinical research.
