DBU-Catalyzed Diastereo/Regioselective Access to Highly Substituted Spiro-oxetane Oxindoles via Ring Annulation of Isatins and Allenoates

dc.contributor.author	Durugappa, B
dc.contributor.author	Athira, C S
dc.contributor.author	Doddamani, S V
dc.contributor.author	Somappa, S B
dc.date.accessioned	2023-11-28T10:59:13Z
dc.date.available	2023-11-28T10:59:13Z
dc.date.issued	2023-07-07
dc.identifier.citation	The Journal of Organic Chemistry;88(13):8882-8888	en_US
dc.identifier.uri	https://doi.org/10.1021/acs.joc.3c00664
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/4637
dc.description.abstract	A facile and efficient method for the diastereo/regioselective synthesis of highly functionalized spiro-oxetane oxindoles has been described. The 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed reaction proceeds via spiro-annulation of isatins and allenoates. The reaction is compatible with a wide range of isatins containing electron-donating groups (EDGs) and electron-withdrawing groups (EWGs) with various allenoates affording the corresponding products in acceptable yields. It is noteworthy that this is the first protocol for constructing structurally diverse motifs of highly functionalized spiro-oxetane oxindoles of pharmaceutical relevance.	en_US
dc.language.iso	en	en_US
dc.publisher	ACS Publications	en_US
dc.subject	Isatins	en_US
dc.subject	Allenoates	en_US
dc.subject	Spiro-oxetane Oxindoles	en_US
dc.title	DBU-Catalyzed Diastereo/Regioselective Access to Highly Substituted Spiro-oxetane Oxindoles via Ring Annulation of Isatins and Allenoates	en_US
dc.type	Article	en_US