Meso-tetrakis(p-sulfonatophenyl)N-confused porphyrin tetrasodium salt: a potential sensitizer for photodynamic therapy

Ajesh P Thomas; Saneesh Babu, P S; Asha Nair, S; Ramakrishnan, S; Ramaiah, D; Chandrashekar, T K; Srinivasan, A; Radhakrishna Pillai, M

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dc.contributor.author	Ajesh P Thomas
dc.contributor.author	Saneesh Babu, P S
dc.contributor.author	Asha Nair, S
dc.contributor.author	Ramakrishnan, S
dc.contributor.author	Ramaiah, D
dc.contributor.author	Chandrashekar, T K
dc.contributor.author	Srinivasan, A
dc.contributor.author	Radhakrishna Pillai, M
dc.date.accessioned	2013-06-17T11:08:10Z
dc.date.available	2013-06-17T11:08:10Z
dc.date.issued	2012-06-14
dc.identifier.citation	Journal of Medicinal Chemistry 55(11):5110-5120;14 Jun 2012	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/477
dc.description.abstract	A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC50 values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS)generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	N-confused porphyrin	en_US
dc.subject	Photodynamic therapy	en_US
dc.subject	Photosensitizer	en_US
dc.subject	Singlet oxygen generation	en_US
dc.subject	Core-modified porphyrins	en_US
dc.subject	Photophysical properties	en_US
dc.subject	Induced apoptosis	en_US
dc.title	Meso-tetrakis(p-sulfonatophenyl)N-confused porphyrin tetrasodium salt: a potential sensitizer for photodynamic therapy	en_US
dc.type	Article	en_US
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