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Reactive Oxygen Species (ROS) Mediated Enhanced Anti-Candidal Activity Of Zns-Zno Nanocomposites with Low Inhibitory Concentrations

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dc.contributor.author Suyan, P
dc.contributor.author Kumar, S N
dc.contributor.author Madhavan, N
dc.contributor.author Kumar, B S D
dc.contributor.author Nair, B N
dc.contributor.author Mohamed, A P
dc.contributor.author Warrier, K G K
dc.contributor.author Hareesh, U S
dc.date.accessioned 2024-02-27T10:30:05Z
dc.date.available 2024-02-27T10:30:05Z
dc.date.issued 2015
dc.identifier.citation RSC Advances;5:76718–76728 en_US
dc.identifier.uri https://doi.org/10.1039/c5ra13316e
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/4781
dc.description.abstract Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS–ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution. en_US
dc.language.iso en en_US
dc.publisher Royal society of chemistry en_US
dc.subject oxygen species en_US
dc.subject ZnS–ZnO en_US
dc.title Reactive Oxygen Species (ROS) Mediated Enhanced Anti-Candidal Activity Of Zns-Zno Nanocomposites with Low Inhibitory Concentrations en_US
dc.type Article en_US


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