An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides

Nayana Joseph; Rani Rajan; Jubi John; Devika, N V; Sarath Chand, S; Suresh, E; Pihko, P M; Radhakrishnan, K V

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dc.contributor.author	Nayana Joseph
dc.contributor.author	Rani Rajan
dc.contributor.author	Jubi John
dc.contributor.author	Devika, N V
dc.contributor.author	Sarath Chand, S
dc.contributor.author	Suresh, E
dc.contributor.author	Pihko, P M
dc.contributor.author	Radhakrishnan, K V
dc.date.accessioned	2013-09-28T04:40:09Z
dc.date.available	2013-09-28T04:40:09Z
dc.date.issued	2013
dc.identifier.citation	RSC Advances 3(21):7751-7757;2013	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/632
dc.description.abstract	A simple and efficient method for the stereoselective ring opening of bicyclic hydrazines with various aryl halides under palladium catalysis has been elaborated. The reactions afforded trans-3,4-disubstituted cyclopentenes or alkylidene cyclopentenes in good to excellent yields. By taking advantage of multiple points of functionalization in the synthesized trans-3-phenyl-4-hydrazino-cyclopentene, we have synthesized the antidepressant Cypenamine (trans-2-phenylcyclopentylamine).	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Meso bicyclic hydrazines	en_US
dc.subject	Facile synthesis	en_US
dc.subject	Enantioselective desymmetrization	en_US
dc.subject	Functionalized cyclopentenes	en_US
dc.subject	Stereoselective-synthesis	en_US
dc.subject	Glycosidase inhibitors	en_US
dc.subject	Diazabicyclic alkenes	en_US
dc.subject	Tertiary-amines	en_US
dc.subject	Reagents	en_US
dc.subject	Cyclopentannulation	en_US
dc.title	An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides	en_US
dc.type	Article	en_US