Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro

Divya, L; Werngren, J; Jose, L; Suja, K P; Mangalam S Nair; Luxmi Varma, R; Sathish, M; Hoffner, S; Kumar, R A

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dc.contributor.author	Divya, L
dc.contributor.author	Werngren, J
dc.contributor.author	Jose, L
dc.contributor.author	Suja, K P
dc.contributor.author	Mangalam S Nair
dc.contributor.author	Luxmi Varma, R
dc.contributor.author	Sathish, M
dc.contributor.author	Hoffner, S
dc.contributor.author	Kumar, R A
dc.date.accessioned	2013-11-13T08:05:53Z
dc.date.available	2013-11-13T08:05:53Z
dc.date.issued	2011
dc.identifier.citation	Fitoterapia 82(5):757-761;Jul 2011	en_US
dc.identifier.issn	0367-326X
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/739
dc.description.abstract	Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA). EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485 mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.subject	Antimycobacterial	en_US
dc.subject	M. tuberculosis	en_US
dc.subject	K. galangal	en_US
dc.subject	REMA	en_US
dc.subject	Ethyl p-methoxycinnamate	en_US
dc.title	Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro	en_US
dc.type	Article	en_US