Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode

dc.contributor.author	Nishanth Kumar
dc.contributor.author	Gorantla, J N
dc.contributor.author	Mohandas, C
dc.contributor.author	Bala Nambisan
dc.contributor.author	Ravi S Lankalapalli
dc.date.accessioned	2013-12-20T09:37:26Z
dc.date.available	2013-12-20T09:37:26Z
dc.date.issued	2013
dc.identifier.citation	Natural Product Research 27(23):2168–2172;2013	en_US
dc.identifier.issn	1478-6419
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/963
dc.description.abstract	Bacillus sp. associated with an entomopathogenic nematode is shown to produce diketopiperazine (DKP) that showed stronger antifungal activity against Colletotrichum gloeosporioides [minimum inhibitory concentration (MIC): 8mgmL21] than commercial fungicide oligochitosan (MIC: 125 mgmL21). DKP identified as cyclo(DTyr- L-Leu) was isolated for the first time from a natural source with a D-tyrosine residue. This report also demonstrates for the first time an antifungal property exploration of cyclo(Tyr-Leu) class of dipeptides. The structural elucidation was carried out using 1D, 2D NMR methods and HPLC.	en_US
dc.language.iso	en	en_US
dc.publisher	Taylor & Francis	en_US
dc.subject	Diketopiperazine	en_US
dc.subject	Antifungal activity	en_US
dc.subject	Minimum inhibitory concentration	en_US
dc.subject	Disc diffusion method	en_US
dc.title	Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode	en_US
dc.type	Article	en_US